Department of Biological and Material Sciences in Dentistry, Faculty of Health, Witten/Herdecke University, Alfred-Herrhausen-Strasse 44, 58455, Witten, Germany. Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK. Department of Biological and Material Sciences in Dentistry, Faculty of Health, Witten/Herdecke University, Alfred-Herrhausen-Strasse 44, 58455, Witten, Germany. wolfgang.arnold@uni-wh.de.